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This section briefly reviews the main papers on R&D cooperation modeled as games, but it is not meant to be an exhaustive survey. It also compares the concept of trust as developed in this paper with the existing notions. 2.1. R&D cooperation between symmetric non-opportunist firms The first models on R&D cooperation considered the simple context of identical non-opportunist firms in order to examine the conditions under which R&D cooperation promotes private and social welfare. They showed that R&D cooperation might be motivated by cost and information sharing in the presence of spillovers. When spillovers are high, R&D cartels involving cost and information sharing ; call for high R&D expenditures. This leads to economies of scale in terms of cost reduction, since each firm also benefits from the increased R&D efforts of other firms, given the high level of spillovers. The seminal article by d'Aspremont and Jacquemin 1988 ; is one of the most influential papers in this group. Their basic R&D cartel model in a duopoly framework has now been extended along various lines, with the consideration of oligopolies, heterogeneous products, product innovation, vertical cooperation, participation in multiple R&D cartels, multiple participants, etc. Kamien et al. 1992; Motta, 1992; Suzumura, 1992; Ziss, 1994; DeBondt, 1997; Hinloopen, 2000 ; . More recent models have also confirmed the preceding results taking into account the endogenization of spillovers Katsoulacos and Ulph, 1998; Poyago-Theotoky, 1999 ; . Another set of models studies the impact of spillovers in a stochastic or dynamic context. When spillovers or imitations are likely, R&D cartels are again initiated due to the internalization of market spillovers of knowledge and non-duplication of research efforts Grossman and Shapiro, 1987; Beath et al. 1988; Katsoulacos, 1988; Choi, 1993 ; . A third set focuses on the incentives for R&D cooperation in the absence of spillovers. Marjit 1991 ; shows that when the, because extracting hydrocodone.
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1. Iglehart JK. The American health care system--expenditures. N Engl J Med. 1999; 340: 70-76. Kong D. US efforts urged to check high pharmaceutical costs. Boston Globe. July 28, 1999: A8. 3. Mehl B, Santell JP. Projecting future drug expenditures--1999. J Health Syst Pharm. 1999; 56: 31-39. Glickman L, Bruce EA, Caro FG, Avorn J. Physicians' knowledge of drug costs for the elderly. J Geriatr Soc. 1994; 42: 992-996. Hoffman J, Barefield FA, Ramamurthy S. A survey of physician knowledge of drug costs. J Pain Symptom Manage. 1995; 10: 432-435. Oppenheim GL, Erickson SH, Ashworth C. The family physician's knowledge of the cost of prescribed drugs. J Fam Pract. 1981; 12: 1027-1030. Weber ML, Auger C, Cleroux R. Knowledge of medical students, pediatric residents, and pediatricians about the cost of some medications. Pediatr Pharmacol. 1986; 5: 281-285. Rowe J, MacVicar S. Doctors' knowledge of the cost of common medications. J Clin Hosp Pharm. 1986; 11: 365-368. Miller LG, Blum A. Physician awareness of prescription drug costs: a missing element of drug advertising and promotion. J Fam Pract. 1993; 36: 33-36. Ryan M, Yule B, Bond C, Taylor RJ. Scottish general practitioners' attitudes and knowledge in respect of prescribing costs. BMJ. 1990; 300: 1316-1318. Fowkes FG. Doctors' knowledge of the costs of medical care. Med Educ. 1985; 19: 113-117. Beringer GB, Biel M, Ziegler DK. Neurologists' knowledge of medication costs. Neurology. 1984; 34: 121-122. Walzak D, Swindells S, Bhardwaj A. Primary care physicians and the cost of drugs: a study of prescribing practices based on recognition and information sources. J Clin Pharmacol. 1994; 34: 1159-1163. Stuart B, Grana J. Ability to pay and the decision to medicate. Med Care. 1998; 36: 202-211. Soumerai SB, Ross-Degnan D. Inadequate prescription-drug coverage for Medicare enrollees--a call to action. N Engl J Med. 1999; 340: 722-728. Rother J. A drug benefit: the necessary prescription for Medicare. Health Aff Millwood ; . July-August 1999; 18: 20-24. Etheredge L. Purchasing Medicare prescription drug benefits: a new proposal. Health Aff Millwood ; . July-August 1999; 18: 7-19. Gross D, Branagan N. Medicare Beneficiaries and Prescription Drug Coverage: Gaps and Barriers. Washington, DC: AARP Public Policy Institute; 1999. 19. Davis M, Poisal J, Chulis G, Zarabozo C, Cooper B. Prescription drug coverage, utilization, and spending among Medicare beneficiaries. Health Aff Millwood ; . January-February 1999; 18: 231-243. Cardinale V, ed. 1998 Drug Topics Red Book. Montvale, NJ: Medical Economics Co; 1998. 21. Ziegler MG, Lew P, Singer BC. The accuracy of drug information from pharmaceutical sales representatives. JAMA. 1995; 273: 1296-1298. Lexchin J. What information do physicians receive from pharmaceutical representatives [review]? Can Fam Physician. 1997; 43: 941-945. Caudill TS, Johnson MS, Rich EC, McKinney WP. Physicians, pharmaceutical sales representatives, and the cost of prescribing. Arch Fam Med. 1996; 5: 201-206. McKinney WP, Schiedermayer DL, Lurie N, Simpson, DE, Goodman JL, Rich, EC. Attitudes of internal medicine faculty and residents toward professional interaction with pharmaceutical sales representatives. JAMA. 1990; 264: 1693-1697.
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